**Job Description & Responsibilities**

Pfizer is seeking a Senior Scientist in AI-Enabled Structural Biology to advance structure-based discovery by integrating AI-guided protein design, structure prediction, and cryo-electron microscopy (cryo-EM), including AI/ML-enabled data analysis. This role is intended for a scientist who can apply and adapt state-of-the-art protein design methodologies to translate computational approaches into experimentally tractable solutions and leverage AI/ML approaches to accelerate structural discovery. In particular, the candidate will utilize de novo designed proteins, engineered constructs, scaffolds, and conformational stabilizers to expand structural access and mechanistic understanding of challenging targets for structure-based drug design (SBDD) across diverse modalities, including small molecules, biologics, and vaccine antigens.

The successful candidate will operate at the interface of structural biology, AI-driven discovery, an...