Project title

“Functional and mechanistic study of CPT1C in neuronal and glioblastoma models: metabolic regulation, Warburg phenotype and protein interaction networks.”

Project description

The Neurolipid Group ( at Universitat Internacional de Catalunya (UIC Barcelona) is looking for a highly motivated predoctoral student to join a research project focused on the cellular and metabolic functions of Carnitine Palmitoyltransferase 1C (CPT1C). CPT1C is an atypical member of the CPT1 protein family. Unlike CPT1A and CPT1B, CPT1C does not display classical carnitine palmitoyltransferase enzymatic activity. Instead, CPT1C is mainly localized at the endoplasmic reticulum and is highly expressed in neurons, where it is thought to act as a metabolic sensor and regulator of cellular adaptation to nutritional and energetic stress. CPT1C has also been found to be overexpressed in several tumour types, including glioblastoma, suggesting that this protein may contri...