Location
New York
Posted
June 16, 2026
Commute
Local Area
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Job Description
**Job Description**
**_Roles & Responsibilities:_**
The Guccione Lab at the Icahn School of Medicine at Mount Sinai recently identified that inhibiting spliceosomal assembly through inhibition of arginine methylation provides an effective means of therapeutic splicing inhibition. Specifically, inhibiting either symmetric arginine methylation (mediated by the protein arginine methyltransferase 5 -PRMT5) or asymmetric dimethyl arginine methylation (mediated by type I PRMTs (PRMT1, 3, 4, and 6)) reduces splicing fidelity resulting in strong preferential killing of (i) splicing factor-mutant leukemias and (ii) MYC-overexpressing lymphomas over their wildtype counterparts. In addition the lab is investigating the role of members of the PRDM family of enzymes (e.g. PRDM9, PRDM10, PRDM15), in liver and colorectal cancer.
The successful applicant will be part of a highly productive research team studying transcription and post-transcriptional regulation in the contex...
**_Roles & Responsibilities:_**
The Guccione Lab at the Icahn School of Medicine at Mount Sinai recently identified that inhibiting spliceosomal assembly through inhibition of arginine methylation provides an effective means of therapeutic splicing inhibition. Specifically, inhibiting either symmetric arginine methylation (mediated by the protein arginine methyltransferase 5 -PRMT5) or asymmetric dimethyl arginine methylation (mediated by type I PRMTs (PRMT1, 3, 4, and 6)) reduces splicing fidelity resulting in strong preferential killing of (i) splicing factor-mutant leukemias and (ii) MYC-overexpressing lymphomas over their wildtype counterparts. In addition the lab is investigating the role of members of the PRDM family of enzymes (e.g. PRDM9, PRDM10, PRDM15), in liver and colorectal cancer.
The successful applicant will be part of a highly productive research team studying transcription and post-transcriptional regulation in the contex...