E11 Bio is a Focused Research Organization (FRO) with a long-term mission to make connectomics scalable and cost-effective in mammalian brains – first in mice, and eventually in humans. We have recently developed PRISM, a platform technology for low cost optical connectomics. PRISM integrates advances in genetic cell barcoding, multiplexed expansion microscopy, and ML reconstruction to solve key bottlenecks in data acquisition and analysis. We anticipate that PRISM, with further development, will reduce the cost of connectomics 100-fold and thereby transform brain understanding, treatments for brain disorders, and neuro-inspired computing. As an ML scientist at E11 Bio, you will develop innovative and scalable methods to realize the potential of optical barcode connectomics. This is a unique opportunity to play a key role in a moonshot non-profit neuroscience project. It is also an opportunity to help pioneer our FRO model, which combines the best parts of non-profit team sci...